The optimization schedule allows you to select the days of the week and the frequency at which the Pontiac algorithm will make optimizations to your campaign. To allow the algorithm to learn effectively we recommend optimizing only once per week to start. 
When your campaign reaches 35-50 clicks a day (if KPI is CTR) or 35-50 conversions a day (if KPI is CPA), you can change this to two to three times a week.